The worldwide rat model market is anticipated to reach USD 845 million by 2025. The market stood at USD 412.3 million in 2016. Driven by development of novel medical devices & biotechnology products, it is projected to grow at an 8.3% CAGR over the forecast period (2014 to 2025). High prevalence of neurodegenerative & immunology disorders worldwide is expected to boost product demand.
Rat models are model organisms used in researching diseases and their respective vaccines & drugs. Over the years, these have been used to study autism, type 2 diabetes mellitus, neural regeneration, and autoimmune disorders. Transgenic rats have virus strains inserted into their DNA through genetic splicing or other methods. Scientists at Sigma-Aldrich have managed to produce knockout rats with selective gene deletions. These rodents can be used in further medical research.
Innovations in creating better rat models have led to the advent of technologies such as Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR), zinc finger nuclease (ZFN), and transcription activator-like effector nucleases (TALENs). These rat models act as a precursor to novel drug development. Interestingly, a breakthrough in the treatment of Alzheimer’s disease has been observed in rat models when a certain protein is used to reverse the degeneration of brain cells. Brain-derived neurotrophic factor (BDNF) is a protein that acts on dying brain cells, reverses memory loss, and renders cognitive development in rats. It holds immense potential for future research in treating brain degenerative disorders in humans.
In-depth research report on global rat model market - http://www.grandviewresearch.com/industry-analysis/rat-model-market
The global rat model market is fragmented according to types, technologies, services, applications, end use, and regions. Types of rat models are inbred, outbred, knockout, conditioned, immunodeficient, and hybrid. Outbred held a major market share in 2015 on account of genetic variations in rat strains which can be traced back to four generations. These rat models can predict results of the same drug in individual rats. Other rat models that are rapidly gaining popularity are conditioned, knockout, and hybrid.
According to technologies, the divisions are embryonic stem cell, nuclear transferase, microinjection, and others. “Others” dominates the market owing to high use of CRISPR technology. Demand for genetically modified & conditioned animals is another vital factor that fuels this segment. “Others” includes vector-mediated gene transfer, ZFN, and biolistics. Microinjection is anticipated to grow robustly till 2025 due to lesser breeding time in rats.
Services include quarantine, rederivation, breeding, cryopreservation, genetic testing, and others. With a share over 30%, breeding led the global market in 2016. It is expected to dominate the services segment over the forecast period. Cryopreservation is projected to witness high growth during the same period.
On the basis of applications, the market is categorized into toxicology, neurology, immunology, oncology, and others. Neurology is expected to generate substantial revenues due to increasing production of conditioned rats for research on neurological disorders like Alzheimer’s. Toxicology is anticipated to drive the worldwide market over the forecast period. This can be attributed to the proliferation of various contract research organizations (CROs) offering such services.
According to end use, the overall market is classified as healthcare companies, academic & research institutes, and contract research organizations (CROs). Healthcare companies held the largest share in 2016. The rapid proliferation of CROs is anticipated to positively impact product demand over the forecast period. As per regions, the worldwide market is segmented into Latin America, North America, Middle East & Africa (MEA), Asia Pacific (APAC), and Europe. It is expected that APAC will hold a market share over 10% by 2025. Low expenditure on research activities in India, Singapore, and Thailand may drive this region in the years to come.
Notable players of the global rat model market are genOway S.A.; Horizon Discovery Group Plc.; Taconic Biosciences, Inc.; Charles River Laboratories (CRL); and Biomedical Research Models, Inc. The market is characterized by intense competition with frequent entry of small & medium-scale companies. Mergers & acquisitions are common business expansion strategies often adopted by these players to thrive and prosper in the long run.